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    News — endocannabinoid system

    CBD Oils & CBD Tinctures

    CBD Oils & CBD Tinctures

    A common misunderstanding in the cannabis industry is that CBD oil and tinctures are the same product. Although they are closely related, they have several distinct properties that differentiate the two. Both products can be extracted from either the hemp plant or the cannabis plant, sourced from the stalk or seed, but most often times and most importantly, the flower.

    CBD OIL

    CBD oil is typically extracted with propane, butane, or CO2, making it a thicker product with higher concentrations of cannabinoids, the natural chemical compounds that give patients their desired effects from cannabis. With this extraction method, more of the vitamins and nutrients are still intact, as well as other natural pieces of the plants such as proteins, chlorophyll, fatty acids, and flavonoids that all have their own quality to bring to CBD oil. CBD oil usually retains most of its original earthy, floral flavor because the way it holds onto all of these parts of the plant. Many people take their CBD oil orally for quickest onset, but it can also be ingested via capsule to be digested for an extended release because it is so thick. 

     

    CBD TINCTURES

    CBD tinctures, on the other hand, are typically extracted with alcohol or glycerin and are liquid at room temperature. Sometimes, to retain this liquidity, filler substances such as MCT oil (medium-chain triglyceride AKA refined coconut oil) are added. Some companies opt to add some flavoring to their tinctures for easier and tastier consumption, as this product is taken sublingually (under the tongue) or added to a beverage. 

    Both CBD oil and CBD tinctures, when taken sublingually, the cannabinoids are sent into the bloodstream via the blood vessels underneath the tongue. Consumer experience will depend on the strength of the product, how much ingested, and the individual’s metabolism and body processes.  It never hurts to try both products to see which may be more effective for you.

    40 Million US Adults Have an Anxiety Disorder. Can CBD Help?

    40 Million US Adults Have an Anxiety Disorder. Can CBD Help?

    As laws and social stigmas change, the cannabis plant, namely its chemical compounds of cannabinoids, is gaining more notability for having effective anti-anxiety effects on people across the globe. In a recent study on cannabidiol (CBD) and neuropsychiatric, or anxiety, disorders, it was shown that preclinical evidence strongly supports CBD as a treatment for the following disorders: generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. There is a need for studies to investigate chronic CBD dosing and clinical populations, but this study used acute doses of CBD to explore the effects of cannabidiol to calm the fear response in the body.

    Fear and anxiety, as adaptive responses that are necessary for coping with threats to survival, can easily get excessive or persistent and can lead to disability when systems are imbalanced. When this happens, people typically show a diminished sense of well-being, have a hard time in healthy relationships, are more prone to unemployment, and also exhibit an elevated suicide risk. So it’s no wonder that we are exploring CBD as a natural and healthy alternative to help combat these disruptive responses. In the United States, twenty-nine percent of the population has a lifetime prevalence of anxiety disorders, the highest of any mental disorder. This in turn creates massive social and economic burdens as this large of a population struggles with day to day structures such as relationships and jobs. Currently, pharmaceuticals such as benzodiazepines, antidepressants, and serotonin reuptake inhibitors are prescribed to treat these conditions, but sometimes, at a high cost. CBD, with further study, is showing excellent safety ratings for high doses, which is unlike many of the pharmaceutical options out there with high overdose and abuse rates. This study showed that CBD was well-tolerated across a wide dose range, up to 1500mg/day (orally), without any reported psychomotor slowing, negative mood effects, or abnormalities in vital signs. 

    The way CBD interacts with the brain’s chemistry has to do with the endocannabinoid system, which is responsible for the body’s way of maintaining homeostasis, or balance, as well as other diverse physiological functions such as caloric energy balance and immune function. Several of these receptors found throughout the endocannabinoid system are known to regulate fear and anxiety-related behaviors, specifically the CB1 receptor and the serotonin 5-HT receptor (joyfulness), among several other receptors throughout the body’s nervous system. A system that is healthy has a natural and balanced response to fear-triggering events, whereas one that is experiencing disorder, does not have that regulated response and creates a malfunction.

    The way CBD can work on regulating this response has to do with the CB1 receptor - its activation has the ability to minimize conditioned fear responses and can prevent it from coming back unnecessarily, by releasing a hormone corticotropin, which has anti-anxiety effects. That said, when these receptors are activated on a consistent basis, it can help prevent the negative effects that fear has on the body, such as aging and stress. Chronic stress impairs the endocannabinoid system’s signaling to various parts of the brain (the hippocampus and amygdala), which leads to anxiety. Basically, cannabinoids have been shown to be activators for this balanced and natural response of the system to regulate fear, not block it.

    Although this study had its limitations, as only experimentally-induced anxiety or fear was studied, it was shown that CBD reduced anxiety with a simulated public speaking test in healthy subjects and also those suffering from social anxiety disorder, and proved to be comparable to pharmaceutical medications in their efficiency. Taken at high doses ranging from 300 to 600mg, CBD was shown to reduce anxiety in healthy people without affecting baseline anxiety levels, or a balanced anxiety response, and also significantly reduced anxiety in patients with social anxiety disorder. This means that this evidence may support the use of CBD for aiding potential treatment for PTSD or enhancing cognitive behavioral therapy, which could change this problem in the United States. 

    CBD for Dravet Syndrome - A 2017 Study

    CBD for Dravet Syndrome - A 2017 Study

    Dravet syndrome, previously known as severe myoclonic epilepsy of infancy (SMEI), is a severe form of epilepsy that typically develops around 6 months of age. Starting with frequent febrile seizures which are fever-related, seizures can be triggered by body temperature changes, flashing lights, emotional stress or excitement. As the disease progresses, the patient may develop myoclonic seizures, characterized by involuntary muscle spasms, and status epilepticus, a state of continuous seizure that lasts longer than 30 minutes and requires emergency care.

    The high frequency of seizures caused by the syndrome commonly causes children to have trouble developing language and motor skills. In addition, they often experience hyperactivity and have problems with socialization. Dravet syndrome is typically treated with anticonvulsant medications and diet adjustment, with varying results from person to person. Seizures associated with Dravet syndrome are particularly difficult to control compared to other forms of epilepsy.

    While there is no cure for Dravet syndrome, a 2017 study published in the New England Journal of Medicine demonstrated that cannabis might play a role in reducing seizures caused by Dravet syndrome. One of the major cannabinoids found in cannabis, cannabidiol (CBD), interacts with cannabinoid receptor 1 in the body’s endocannabinoid system, inhibiting the release of a certain neurotransmitter that causes seizures. The study, which is the largest and most successful clinical trial to-date to demonstrate the potential medicinal benefits of CBD, may convince many clinicians to consider CBD for treating the 20% of epileptic disorder that are poorly controlled by prescription drugs.

    According to the National Institute of Health, CBD-enriched cannabis reduced seizure frequency in 85% of children and 14% reported complete seizure freedom. Children also saw improvements in sleep (53%), alertness (71%), and mood (63%). Furthermore, these benefits were achieved with minimal side effects.

    CBD was approved for use in the treatment of Dravet syndrome in 2018, and studies continue to demonstrate its effectiveness. Tell us your experiences in the comments.

    We are Fully Activating the Paintball World with CBD!

    We are Fully Activating the Paintball World with CBD!

    As the head product ambassador for Fully Activated, I am always looking at ways to reach out to new demographics that can benefit from our products. Every living being with an endocannabinoid system stands to benefit from CBD. As a semi-professional paintball player, I knew my paintball community needed to experience the wonders of Fully Activated. Week in and week out, all year around, we are beating up our bodies; running, diving, sliding, and getting hit with paintballs flying 300 feet per second (over 200mph!) which forms welts and leaves bruises in their wake.

     

    Fully Activated is proud to be a “Platinum Sponsor” (the highest level of support) for the National Xball League, which is the largest and most professional platform for tournament paintball. The NXL features multiple divisions of competition, and hosts 5 tournaments in the United States and 5 in Europe over the course of the year. Teams fly in from around the world to prove themselves and showcase their skills.

     

    Tournament paintball, often referred to as “speedball”, “airball”, and “Xball” is played on a rectangular 120ft x 150ft level surface, with 48 inflatable bunkers arranged symmetrically so that each side has the same positions. Five players start on either side of the field at a central spot, and as soon as the horn sounds, it is a fast and furious battle to shoot the other five players and tag the buzzer located where the opposing team started. When you tag the buzzer, your team is awarded one point. There is a 15-minute timer, whichever team gets a spread of five points or has the most points after time expires wins the match! Teams play four preliminary matches to start, and whichever teams have the best records move forward into a single elimination bracket. Teams shoot tens of thousands of paintballs as they compete to win thousands of dollars and the pride of being the best in their division!

     

    Fully Activated is a proud sponsor of San Diego Dynasty, the best professional team in tournament paintball history. Formerly sponsored by the likes of Dell Computer, Intel, and having won five Ford Mustangs in the 2000 Spider Cup tournament, they have been the fiercest competition at this level in the history of the sport. With dozens and dozens of 1st place finishes, their dedication to excellence, consistency, incredible track record, and positive energy and attitudes reflect our company values. Our products help keep them healthy and recovering quickly so they can maintain peak performance.

     

    We are also sponsoring divisional teams from around the country, including Colorado based teams Mile High Saints, Denver Kaos, and a factory team out of Pittsburgh Paintball Park named “Pittsburgh Fully Activated”. We are excited to expose new teams from all over to the Fully Activated lifestyle by sharing free samples, CBD massage, and more at our booth at the NXL events.

     

    The sports recovery market has been sorely missing out; the anti-inflammatory, anti-anxiety, and pain-management properties of CBD are going to change the way we train and recover and level up our performance. We are honored by the positive response from the players and industry leaders of the NXL, and are looking forward to helping paintball players stay injury free and achieve maximum wellness!

     

    2019 NXL US Tournament Schedule:
    March 8-10 Las Vegas
    May 2-5 Dallas/Fort Worth
    June 20-23 Philadelphia
    September 12-15 Chicago
    November 6-10 Orlando “World Cup”

    How Does CBD Work with the Endocannabinoid System?

    How Does CBD Work with the Endocannabinoid System?

    What is a Cannabinoid?

    A cannabinoid is a chemical compound found in plants and the human body.  Plant cannabinoids are known as phytocannabinoids, and cannabinoids made by mammals are known as endocannabinoids.  You may have heard of a few popular phytocannabinoids, such as THC and CBD which are found in the cannabis plant, along with over 100 more like CBG & CBN.   

    Cannabinoid receptors (microscopic connectors where cannabinoids interact with the body) are found most concentrated in the central and peripheral nervous systems.  While the human brain has the most known cannabinoid receptors, the heart, adrenal glands, male & female reproductive organs, lungs, bone marrow, and tonsils also have receptors.  Humans are not the only ones with endocannabinoid systems since your dog & lizard have them, too!  Read more about Pets and CBD

     

     

    How Does the Endocannabinoid System Work?

    Cannabinoids & cannabinoid receptors make up the endocannabinoid system.  Cannabinoids bind with the cannabinoid receptors in the body to effect its communication system, also known as your neurotransmitters.  For example, neurotransmitters receive information from your nerve endings that you’re touching something hot and send the signal your brain.  In return, your brain responds by signaling your hand to move off of the stove.  Neurotransmitters can also tell the brain when you get the flu so it can send healthy cells to fight the infection, or when you break your arm.  Cannabinoids, like CBD (cannabidiol), have been shown to potentially down-regulate the inflammatory response in the body and reduce chronic pain.  Ultimately, CBD interferes to reduce pain-causing inflammation.  Read more on CBD and Pain

    Studies on CBD have shown that it does not appear to have psychotropic effects, meaning you won’t feel high like with THC, but it may have anti-anxiety  effects.  Commonly, CBD comes in two varieties - Full Spectrum Distillate, meaning it offers an array of CBD with other cannabinoids & terpenes, or Isolate, which comes in powder form and it 90%+ pure CBD without other cannabinoids.  Read more on Full Spectrum vs Isolate

    CBD can be taken a number of ways: inhalation through smoking or vaporizing, buccal or sublingually under the tongue, swallowed internally, or used topically on the skin.   There are a wide number of products out there like topical skin salves, under the tongue tinctures, CBD-only isolate, Full spectrum distillate, capsules, oils, vape juice, and many others.  See what we have to offer!