A common misunderstanding in the cannabis industry is that CBD oil and tinctures are the same product. Although they are closely related, they have several distinct properties that differentiate the two. Both products can be extracted from either the hemp plant or the cannabis plant, sourced from the stalk or seed, but most often times and most importantly, the flower.
CBD oil is typically extracted with propane, butane, or CO2, making it a thicker product with higher concentrations of cannabinoids, the natural chemical compounds that give patients their desired effects from cannabis. With this extraction method, more of the vitamins and nutrients are still intact, as well as other natural pieces of the plants such as proteins, chlorophyll, fatty acids, and flavonoids that all have their own quality to bring to CBD oil. CBD oil usually retains most of its original earthy, floral flavor because the way it holds onto all of these parts of the plant. Many people take their CBD oil orally for quickest onset, but it can also be ingested via capsule to be digested for an extended release because it is so thick.
CBD tinctures, on the other hand, are typically extracted with alcohol or glycerin and are liquid at room temperature. Sometimes, to retain this liquidity, filler substances such as MCT oil (medium-chain triglyceride AKA refined coconut oil) are added. Some companies opt to add some flavoring to their tinctures for easier and tastier consumption, as this product is taken sublingually (under the tongue) or added to a beverage.
Both CBD oil and CBD tinctures, when taken sublingually, the cannabinoids are sent into the bloodstream via the blood vessels underneath the tongue. Consumer experience will depend on the strength of the product, how much ingested, and the individual’s metabolism and body processes. It never hurts to try both products to see which may be more effective for you.
As laws and social stigmas change, the cannabis plant, namely its chemical compounds of cannabinoids, is gaining more notability for having effective anti-anxiety effects on people across the globe. In a recent study on cannabidiol (CBD) and neuropsychiatric, or anxiety, disorders, it was shown that preclinical evidence strongly supports CBD as a treatment for the following disorders: generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. There is a need for studies to investigate chronic CBD dosing and clinical populations, but this study used acute doses of CBD to explore the effects of cannabidiol to calm the fear response in the body.
Fear and anxiety, as adaptive responses that are necessary for coping with threats to survival, can easily get excessive or persistent and can lead to disability when systems are imbalanced. When this happens, people typically show a diminished sense of well-being, have a hard time in healthy relationships, are more prone to unemployment, and also exhibit an elevated suicide risk. So it’s no wonder that we are exploring CBD as a natural and healthy alternative to help combat these disruptive responses. In the United States, twenty-nine percent of the population has a lifetime prevalence of anxiety disorders, the highest of any mental disorder. This in turn creates massive social and economic burdens as this large of a population struggles with day to day structures such as relationships and jobs. Currently, pharmaceuticals such as benzodiazepines, antidepressants, and serotonin reuptake inhibitors are prescribed to treat these conditions, but sometimes, at a high cost. CBD, with further study, is showing excellent safety ratings for high doses, which is unlike many of the pharmaceutical options out there with high overdose and abuse rates. This study showed that CBD was well-tolerated across a wide dose range, up to 1500mg/day (orally), without any reported psychomotor slowing, negative mood effects, or abnormalities in vital signs.
The way CBD interacts with the brain’s chemistry has to do with the endocannabinoid system, which is responsible for the body’s way of maintaining homeostasis, or balance, as well as other diverse physiological functions such as caloric energy balance and immune function. Several of these receptors found throughout the endocannabinoid system are known to regulate fear and anxiety-related behaviors, specifically the CB1 receptor and the serotonin 5-HT receptor (joyfulness), among several other receptors throughout the body’s nervous system. A system that is healthy has a natural and balanced response to fear-triggering events, whereas one that is experiencing disorder, does not have that regulated response and creates a malfunction.
The way CBD can work on regulating this response has to do with the CB1 receptor - its activation has the ability to minimize conditioned fear responses and can prevent it from coming back unnecessarily, by releasing a hormone corticotropin, which has anti-anxiety effects. That said, when these receptors are activated on a consistent basis, it can help prevent the negative effects that fear has on the body, such as aging and stress. Chronic stress impairs the endocannabinoid system’s signaling to various parts of the brain (the hippocampus and amygdala), which leads to anxiety. Basically, cannabinoids have been shown to be activators for this balanced and natural response of the system to regulate fear, not block it.
Although this study had its limitations, as only experimentally-induced anxiety or fear was studied, it was shown that CBD reduced anxiety with a simulated public speaking test in healthy subjects and also those suffering from social anxiety disorder, and proved to be comparable to pharmaceutical medications in their efficiency. Taken at high doses ranging from 300 to 600mg, CBD was shown to reduce anxiety in healthy people without affecting baseline anxiety levels, or a balanced anxiety response, and also significantly reduced anxiety in patients with social anxiety disorder. This means that this evidence may support the use of CBD for aiding potential treatment for PTSD or enhancing cognitive behavioral therapy, which could change this problem in the United States.
Dravet syndrome, previously known as severe myoclonic epilepsy of infancy (SMEI), is a severe form of epilepsy that typically develops around 6 months of age. Starting with frequent febrile seizures which are fever-related, seizures can be triggered by body temperature changes, flashing lights, emotional stress or excitement. As the disease progresses, the patient may develop myoclonic seizures, characterized by involuntary muscle spasms, and status epilepticus, a state of continuous seizure that lasts longer than 30 minutes and requires emergency care.
The high frequency of seizures caused by the syndrome commonly causes children to have trouble developing language and motor skills. In addition, they often experience hyperactivity and have problems with socialization. Dravet syndrome is typically treated with anticonvulsant medications and diet adjustment, with varying results from person to person. Seizures associated with Dravet syndrome are particularly difficult to control compared to other forms of epilepsy.
While there is no cure for Dravet syndrome, a 2017 study published in the New England Journal of Medicine demonstrated that cannabis might play a role in reducing seizures caused by Dravet syndrome. One of the major cannabinoids found in cannabis, cannabidiol (CBD), interacts with cannabinoid receptor 1 in the body’s endocannabinoid system, inhibiting the release of a certain neurotransmitter that causes seizures. The study, which is the largest and most successful clinical trial to-date to demonstrate the potential medicinal benefits of CBD, may convince many clinicians to consider CBD for treating the 20% of epileptic disorder that are poorly controlled by prescription drugs.
According to the National Institute of Health, CBD-enriched cannabis reduced seizure frequency in 85% of children and 14% reported complete seizure freedom. Children also saw improvements in sleep (53%), alertness (71%), and mood (63%). Furthermore, these benefits were achieved with minimal side effects.
CBD was approved for use in the treatment of Dravet syndrome in 2018, and studies continue to demonstrate its effectiveness. Tell us your experiences in the comments.
Cannabidiol and Sleep
As the popularity of CBD and CBD products rises, there have been numerous claims surfacing about what it can and cannot help. While research is still very new in regards to cannabidiol, there have been promising studies that are shining light on potential benefits of the hemp plant. Science and research are often limited to studies and experiments that you can fully control, test, and replicate results. The industry is well on its way to exploring hemp’s cannabinoids like CBD, CBN, CBG, etc and there is still so much we don’t know!
This January, a sleep survey was done around CBD and sleep patterns. A group of 4 doctors examined 72 consenting adults who suffered from either anxiety or insomnia every day for a minimum of a month. 47 of the participants noted anxiety, and 25 reported insomnia. All participating patients remained under doctor care and on their regular medications. If a patient had anxiety, they were given their CBD after breakfast. If a patient complained about insomnia, they received their CBD after dinner.
After the first month of treatment, approximately 70% of all 72 patients experienced improvement in their symptoms of anxiety and insomnia. After two months, 41 patients continued and around 65% saw improvements. These changes were shown to be sustained responses over time, as well.
These doctors found that hemp-derived CBD was well tolerated and had few side effects. Some experienced side effects like mild fatigue, which tapered out for most of them after the first two weeks. While this is only one small study, it begins to open up more questions and potential answers for how we further use and integrate hemp and CBD into our routines.
We’ve heard similar stories from members of our Fully Activated community: “This is an amazing product! I’ve been using it for about a month now. I’ve experienced improved mood, decreased anxiety, decreased pain, better sleep and improved blood sugar control (I have T1D)- with no negative side effects! It has really helped my body maintain homeostasis and provides a “subtle fading of whatever ails you” .. this is too good to not share.” - Holly W.
We love hearing our customer’s stories on how CBD helps them in their lives, so please leave us a note so we can share your Fully Activated CBD success story too!